Description

  • Product name

    Recombinant Human SLAMF7/CS1 protein (Fc Chimera)
    See all SLAMF7/CS1 proteins and peptides
  • Purity

    > 95 % SDS-PAGE.

  • Endotoxin level

    < 1.000 Eu/µg
  • Expression system

    HEK 293 cells
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      SGPVKELV GSVGGAVTFP LKSKVKQVDS IVWTFNTTPL VTIQPEGGTI IVTQNRNRER VDFPDGGYSL KLSKLKKNDS GIYYVGIYSS SLQQPSTQEY VLHVYEHLSK PKVTMGLQSN KNGTCVTNLT CCMEHGEEDV IYTWKALGQA ANESHNGSIL PISWRWGESD MTFICVARNP VSRNFSSPIL ARKLCEGAAD DPDSSM
    • Predicted molecular weight

      49 kDa including tags
    • Amino acids

      23 to 226
    • Additional sequence information

      This protein carries a human IgG1 Fc tag at the C terminus. Extracellular domain (AAH27867).

Specifications

Our Abpromise guarantee covers the use of ab221030 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Additional notes

     This product was previously labelled as SLAMF7

     

     This product was previously labelled as SLAMF7

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at 4°C (stable for up to 12 months). Store at -80°C. Avoid freeze / thaw cycle.

    pH: 7.5
    Constituents: 0.61% Tris, 0.75% Glycine, 5% Trehalose

    Lyophilized from 0.22 µm filtered solution.

  • Reconstitution
    It is recommended to reconstitute the lyophilized protein in sterile deionized water to a final concentration of 1 mg/ml. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% HSA or BSA) is strongly recommended for further dilution and long term storage.

General Info

  • Alternative names

    • 19A
    • 19A24 protein
    • CD 319
    • CD2 like receptor activating cytotoxic cells
    • CD2 subset 1
    • CD319
    • CD319 antigen
    • CRACC
    • CS1
    • Membrane protein FOAP 12
    • Novel Ly9
    • Novel LY9 (lymphocyte antigen 9) like protein
    • Protein 19A
    • SLAM family member 7
    • SLAMF 7
    see all
  • Relevance

    SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro). SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. The isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms.
  • Cellular localization

    Membrane; Single-pass type I membrane protein.

Images

  • SDS-PAGE analysis of reduced ab221030 stained overnight with Coomassie Blue. DTT-reduced protein migrates as 60-67 kDa in SDS-PAGE due to glycosylation.

References

ab221030 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab221030.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up