The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Calcium binding mitochondrial carrier superfamily member
Calcium binding mitochondrial carrier superfamily member Aralar1
Calcium-binding mitochondrial carrier protein Aralar1
Mitochondrial aspartate glutamate carrier 1
Solute carrier family 25 (aspartate/glutamate carrier) member 12
Solute carrier family 25 (mitochondrial carrier Aralar) member 12
Solute carrier family 25 member 12
solute carrier family 25, member 12
Calcium-dependent mitochondrial aspartate and glutamate carrier. May have a function in the urea cycle.
High levels in heart and skeletal muscle, low in brain and very low in kidney.
Involvement in disease
Defects in SLC25A12 are the cause of aspartate-glutamate carrier 1 deficiency (AGC1D) [MIM:612949]; also called global cerebral hypomyelination. This syndrome consists of a child severe psychomotor retardation, hypotonia and hypomyelination of the central nervous system.
Belongs to the mitochondrial carrier family. Contains 4 EF-hand domains. Contains 3 Solcar repeats.