The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Chloride anion exchanger
Congenital chloride diarrhea
Down regulated in adenoma
Down regulated in adenoma protein
Down-regulated in adenoma
Solute carrier family 26 member 3
Chloride/bicarbonate exchanger. Involved in absorbtion of in the colon. Helps mediate electrolyte and fluid absorption.
Involvement in disease
Defects in SLC26A3 are the cause of diarrhea type 1 (DIAR1) [MIM:214700]; also known as congenital chloride diarrhea (CLD). DIAR1 is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature.
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. Contains 1 STAS domain.
Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon.
Phosphorylated upon DNA damage, probably by ATM or ATR.