The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
iron regulated gene 1
Iron regulated transporter 1
Iron-regulated transporter 1
putative ferroportin 1 variant IIIA
putative ferroportin 1 variant IIIB
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3, formerly
solute carrier family 40 (iron-regulated transporter), member 1
Solute carrier family 40 member 1
May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).
Expressed in placenta, intestine, muscle and spleen.
Involvement in disease
Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4) [MIM:606069]. HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation.
Belongs to the SLC40A transporter family.
Cell membrane. Localized to the basolateral membrane of polarized epithelial cells.