The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Na(+)/H(+) exchanger 6
Sodium/hydrogen exchanger 6
Solute carrier family 9 (sodium/hydrogen exchanger), isoform 6
Solute carrier family 9 (sodium/hydrogen exchanger), member 6
Solute carrier family 9 member 6
solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis.
Ubiquitous; but is most abundant in mitochondrion-rich tissues such as brain, skeletal muscle and heart.
Involvement in disease
Defects in SLC9A6 are the cause of mental retardation syndromic X-linked Christianson type (MRXSC) [MIM:300243]; also known as MRXS-Christianson or X-linked Angelman-like syndrome. The phenotype is characterized by profound mental retardation, epilepsy, ataxia, and microcephaly, and showed phenotypic overlap with Angelman syndrome.
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Endosome membrane. Is present in the recycling compartments including early and recycling endosomes, and only appears transiently on the plasma membrane.