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Recombinant Human SLCO4C1 protein (ab166349)

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SDS-PAGE - Recombinant Human SLCO4C1 protein (ab166349)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, WB

    Description

    • Product name

      Recombinant Human SLCO4C1 protein
    • Expression system

      Wheat germ
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        MKSAKGIENLAFVPSSPDILRRLSASPSQIEVSALSSDPQRENSQPQELQ KPQEPQKSPEPSLPSAPPNVSEEKLRSLSLSEFEEGSYGWRNFHPQCLQR CNTPGGFLLHYCLLAVTQGIVVNGLVNISISTVEKRYEMKSSLTGLISSS YDISFCLLSLFVSFFGERGHKPRWLAFAAFMIGLGALVFSLPQFFSGEYK LGSLFEDTCVTTRNSTSCTSSTSSLSNYLYVFILGQLLLGAGGTPLYTLG TAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGES TDVTEDDPRWLGAWWIGFLLSWIFAWSLIIPFSCFPKHLPGTAEIQAGKT SQAHQSNSNADVKFGKSIKDFPAALKNLMKNAVFMCLVLSTSSEALITTG FATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTC KNTMKFALFTSGVALTLSFVFMYAKCENEPFAGVSESYNGTGELGNLIAP CNANCNCSRSYYYPVCGDGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIER KTEITSTAETFGFEAKAGKCETHCAKLPIFLCIFFIVIIFTFMAGTPITV SILRCVNHRQRSLALGIQFMVLRLLGTIPGPIIFGFTIDSTCILWDINDC GIKGACWIYDNIKMAHMLVAISVTCKVITMFFNGFAIFLYKPPPSATDVS FHKENAVVTNVLAEQDLNKIVKEG
      • Amino acids

        1 to 724
      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab166349 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      Western blot

    • Form

      Liquid
    • Additional notes

       

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • 9530051F04
      • C330017E21Rik
      • OATP-H
      • OATP-M1
      • Oatp4c1
      • OATPX
      • Organic anion transporter M1
      • PRO2176
      • Slc21A20
      • SLCO4C1
      • SO4C1_HUMAN
      • Solute carrier family 21 member 20
      • Solute carrier organic anion transporter family member 4C1
      see all
    • Function

      Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.
    • Tissue specificity

      Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney.
    • Sequence similarities

      Belongs to the organo anion transporter (TC 2.A.60) family.
      Contains 1 Kazal-like domain.
    • Cellular localization

      Basolateral cell membrane. Detected at the basolateral membrane of the proximal tubule cell in the kidney.
    • Target information above from: UniProt accession Q6ZQN7 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human SLCO4C1 protein (ab166349)
      SDS-PAGE - Recombinant Human SLCO4C1 protein (ab166349)
      ab166349 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab166349? Please let us know so that we can cite the reference in this datasheet.

    ab166349 has not yet been referenced specifically in any publications.

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