Recombinant human SOD2/MnSOD protein (ab167988)

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Description

  • Product name

    Recombinant human SOD2/MnSOD protein
    See all SOD2/MnSOD proteins and peptides

  • Biological activity

    Specific activity is > 1,200 units/mg, in which one unit will inhibit the rate of reduction of cytochrome c by 50% in a coupled system, using xanthine and xanthine oxidase at pH 7.8 at 25°C in a 1.5 ml reaction volume.

  • Purity

    > 95 % SDS-PAGE.

  • Expression system

    Escherichia coli

  • Accession

    P04179

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHH SSGLVPRGSH MKHSLPDLPY DYGALEPHIN AQIMQLHHSK HHAAYVNNLN VTEEKYQEAL AKGDVTAQIA LQPALKFNGG GHINHSIFWT NLSPNGGGEP KGELLEAIKR DFGSFDKFKE KLTAASVGVQ GSGWGWLGFN KERGHLQIAA CPNQDPLQGT TGLIPLLGID VWEHAYYLQY KNVRPDYLKA IWNVINWENV TERYMACKK

    • Predicted molecular weight

      24 kDa including tags

    • Amino acids

      25 to 222

    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab167988 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 79% Tris HCl, 20% Glycerol

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • Indophenoloxidase B
    • IPO B
    • IPOB
    • Manganese containing superoxide dismutase
    • Manganese SOD
    • Manganese superoxide dismutase
    • Mangano superoxide dismutase
    • Mn SOD
    • Mn superoxide dismutase
    • MNSOD
    • MVCD6
    • SOD 2
    • SOD2
    • SODM_HUMAN
    • Superoxide dismutase [Mn] mitochondrial
    • Superoxide dismutase [Mn], mitochondrial
    • Superoxide dismutase 2 mitochondrial
    see all

  • Function

    Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

  • Involvement in disease

    Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

  • Sequence similarities

    Belongs to the iron/manganese superoxide dismutase family.

  • Post-translational
    modifications

    Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.

  • Cellular localization

    Mitochondrion matrix.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant human SOD2/MnSOD protein (ab167988)
    SDS-PAGE - Recombinant human SOD2/MnSOD protein (ab167988)
    15% SDS-PAGE analysis of ab167988 (3 µg).

References

ab167988 has not yet been referenced specifically in any publications.

Publishing research using ab167988? Please let us know so that we can cite the reference in this datasheet.

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