Description

  • Product name

    Recombinant Human SOX2 protein
    See all SOX2 proteins and peptides
  • Purity

    > 90 % SDS-PAGE.
    ab95847 was refolded to soluble form.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      34 kDa

Associated products

Specifications

Our Abpromise guarantee covers the use of ab95847 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Dot blot

    SDS-PAGE

    Indirect ELISA

  • Form

    Liquid
  • Additional notes

    This product is for Research Use Only and not to be used for any commercial resale purpose, including, but not limited to, using the product as part of any developed assay technology such as ELISA, ELISPOT, or Multiplex assay that is sold to another end-user.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 7.50
    Constituents: 0.0555% Calcium chloride, 0.0462% DTT, 1.19% HEPES, 8.7% DL-Arginine, 2.88% Guanidine HCl, 0.0385% Cysteamine

General Info

  • Alternative names

    • ANOP3
    • cb236
    • Delta EF2a
    • lcc
    • MCOPS3
    • MGC148683
    • MGC2413
    • RGD1565646
    • Sex determining region Y box 2
    • SOX 2
    • Sox2
    • SOX2_HUMAN
    • SRY (sex determining region Y) box 2
    • SRY box containing gene 2
    • SRY related HMG box 2
    • SRY related HMG box gene 2
    • SRY-box 2
    • Transcription factor SOX 2
    • Transcription factor SOX-2
    • ysb
    see all
  • Function

    Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency.
  • Involvement in disease

    Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.
  • Sequence similarities

    Contains 1 HMG box DNA-binding domain.
  • Post-translational
    modifications

    Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.
  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • SDS-PAGE analysis of 1.5µg ab95847.
  • anti-SOX2 monoclonal at 1 µg/ml + Recombinant Human SOX2 protein (ab95847) at 0.06 µg
  • Indirect ELISA detection of immobilized ab95847 with titrated amounts of SOX2 Monoclonal Antibody

References

ab95847 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Answer

Thank you for your enquiry.

I would like to reassure you that our product have all been tested successfully and would be covered by our Abpromise guarantee.

Also, although we produce many in-house products, we obtain other products from a wide range of sources. In this case, these products are from different labs. Each product will be recombinant full length human SOX2. The only difference I noted beside those which you have mentioned is that ab79550 has > 95% purity by SDS-PAGE whereas ab95847 has > 90% purity by SDS-PAGE.


I hope that this information is helpful. Please let me know if you have any questions or there are other ways that Abcam may help you meet your research goals.

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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