Overview

  • Product name

    Recombinant Human Spastin protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      PVLPFSKSQTDVYNDSTNLACRNGHLQSESGAVPKRKDPLTHTSNSLPRS KTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTN KPSTP
    • Molecular weight

      37 kDa including tags
    • Amino acids

      200 to 304

Specifications

Our Abpromise guarantee covers the use of ab152700 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • ADPSP
    • FSP 2
    • FSP2
    • KIAA1083
    • Spast
    • Spastic paraplegia 4
    • spastic paraplegia 4 (autosomal dominant; spastin)
    • spastin
    • SPG 4
    • SPG4
    • SPG4 gene
    see all
  • Relevance

    Spastin is thought have a role in microtubule dynamics through its function as a microtubule severing protein. It is localised to the centrosome of neuronal cells but is not found in glial cells. Mutation in the ATPase binding domain of spastin causes hereditary spastic paraplegias (HSP), a large group of clinically similar disorders. Mutant forms of spastin are generally found throughout the cytoplasm rather then within the nucleus.
  • Cellular localization

    Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Endosome, Membrane, Microtubule, Nucleus

Images

  • 12.5% SDS-PAGE analysis of ab152700 stained with Coomassie Blue.

References

This product has been referenced in:

  • Lin YF  et al. Effect of exogenous spastin combined with polyethylene glycol on sciatic nerve injury. Neural Regen Res 14:1271-1279 (2019). Read more (PubMed: 30804259) »
See 1 Publication for this product

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