Overview

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MDPQNQHGSGSSLVVIQQPSLDSRQRLDYEREIQPTAILSLDQIKAIR GSNEYTEGPSVVKRPAPRTAPRQEKHERTHEIIPINVNNNYEHRHTSHLG HAVLPSNARGPILSRSTSTGSAASSGSNSSASSEQGLLGRSPPTRPVPGH RSERAIRTQPKQLIVDDLKGSLKEDLTQHKFICEQCGKCKCGECTAPRTL PSCLACNRQCLCSAESMVEYGTCMCLVKGIFYHCSNDDEGDSYSDNPCSC SQSHCCSRYLCMGAMSLFLPCLLCYPPAKGCLKLCRRCYDWIHRPGCRCK NSNTVYCKLESCPSRGQGKPS
    • Molecular weight

      62 kDa including tags
    • Amino acids

      1 to 318

Associated products

Specifications

Our Abpromise guarantee covers the use of ab132222 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    ELISA

    Western blot

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.

    Previously labelled as Sprouty 1. 

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • hSPRY1
    • Protein sprouty homolog 1
    • Sprouty 1
    • Sprouty homolog 1
    • Sprouty homolog 1 antagonist of FGF signaling
    • Spry-1
    • Spry1
    • SPY1_HUMAN
    see all
  • Function

    May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
  • Sequence similarities

    Belongs to the sprouty family.
    Contains 1 SPR (sprouty) domain.
  • Domain

    The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
  • Cellular localization

    Cytoplasm. Membrane. Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE analysis of ab132222 stained with Coomassie Blue.

References

ab132222 has not yet been referenced specifically in any publications.

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