Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMNGDDTF AKRPRDDAKA SEKRSKAFDD IATYFSKKEW KKMKYSEKIS YVYMKRNYKA MTKLGFKVTL PPFMCNKQAT DFQGNDFDND HNRRIQVEHP QMTFGRLHRI IPKIMPKKPA EDENDSKGVS EASGPQNDGK QLHPPGKANI SEKINKRSGP KRGKHAWTHR LRERKQLVIY EEISDPEEDD E
    • Molecular weight

      24 kDa including tags
    • Amino acids

      1 to 188
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab140577 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity

    > 85 % SDS-PAGE.

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names

    • Cancer/testis antigen 5.1
    • Cancer/testis antigen family 5 member 1
    • CT5.1
    • MGC150425
    • MGC5162
    • Protein SSX1
    • sarcoma, synovial, X chromosome related 1
    • SSRC
    • SSX1
    • SSX1_HUMAN
    • Synovial sarcoma
    • Synovial sarcoma, X breakpoint 1
    • X breakpoint 1
    see all
  • Function

    Could act as a modulator of transcription.
  • Tissue specificity

    Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines.
  • Involvement in disease

    Note=A chromosomal aberration involving SSX1 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
  • Sequence similarities

    Belongs to the SSX family.
    Contains 1 KRAB-related domain.
  • Information by UniProt

Images

  • 15% SDS PAGE analysis of ab140577 (3 µg).

References

ab140577 has not yet been referenced specifically in any publications.

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