Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSLKLNYTT EECDMKKMHY VDPDHVKRAQ KYAQQVLQKE CRPKFAKTSM ALLFEHRYSV DLLPFVQKAP KDSEAESKYD PPFGFRKFSS KVQTLLELLP EHDLPEHLKA KTCRRCVVIG SGGILHGLEL GHTLNQFDVV IRLNSAPVEG YSEHVGNKTT IRMTYPEGAP LSDLEYYSND LFVAVLFKSV DFNWLQAMVK KETLPFWVRL FFWKQVAEKI PLQPKHFRIL NPVIIKETAF DILQYSEPQS RFWGRDKNVP TIGVIAVVLA THLCDEVSLA GFGYDLNQPR TPLHYFDSQC MAAMNFQTMH NVTTETKFLL KLVKEGVVKD LSGGIDREF
    • Molecular weight
      41 kDa
    • Amino acids
      83 to 418
    • Tags
      His tag N-Terminus
    • Additional sequence information
      NP_003887.3. Lumenal.

Specifications

Our Abpromise guarantee covers the use of ab176053 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 85 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Information available upon request.

General Info

  • Alternative names
    • 3-sialyltransferase
    • CMP-NeuAc:lactosylceramide alpha-2
    • CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
    • EC 2.4.99.9
    • Ganglioside GM3 synthase
    • Lactosylceramide alpha-2,3-sialyltransferase
    • Sialyltransferase 9
    • SIAT9
    • SIAT9_HUMAN
    • SIATGM3S
    • ST3 beta-galactoside alpha-2,3-sialyltransferase 5
    • ST3GAL
    • ST3Gal V
    • ST3GAL5
    • ST3GalV
    see all
  • Function
    Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide).
  • Tissue specificity
    Ubiquitous. High expression in brain, skeletal muscle, placenta, and testis.
  • Involvement in disease
    Defects in ST3GAL5 are the cause of Amish infantile epilepsy syndrome (AIES) [MIM:609056]. AIES is an autosomal recessive, infantile-onset symptomatic epilepsy associated with developmental stagnation and blindness.
  • Sequence similarities
    Belongs to the glycosyltransferase 29 family.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localization
    Golgi apparatus membrane.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab176053 (3μg).

References

ab176053 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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