Description

  • Product name

    Recombinant Human STAT2 protein
    See all STAT2 proteins and peptides
  • Purity

    > 90 % SDS-PAGE.
    The purity was determined to be >90% by densitometry
  • Expression system

    Baculovirus infected Sf9 cells
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human

Specifications

Our Abpromise guarantee covers the use of ab43617 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

  • Form

    Liquid
  • Additional notes

    Recombinant full-length human STAT2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.87% Sodium chloride, 25% Glycerol, 0.79% Tris HCl, 0.00385% DTT, 0.00174% PMSF

General Info

  • Alternative names

    • Homo sapiens interferon alpha induced transcriptional activator
    • interferon alpha induced transcriptional activator
    • ISGF 3
    • ISGF3
    • MGC59816
    • P113
    • Signal transducer and activator of transcription 2
    • signal transducer and activator of transcription 2 113kD
    • STAT113
    • Stat2
    • STAT2_HUMAN
    see all
  • Function

    Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
  • Sequence similarities

    Belongs to the transcription factor STAT family.
    Contains 1 SH2 domain.
  • Post-translational
    modifications

    Tyrosine phosphorylated in response to IFN-alpha.
  • Cellular localization

    Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
  • Information by UniProt

Images

  • Demonstration of purity (>90% by densitometry) using western blot.

References

ab43617 has not yet been referenced specifically in any publications.

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