Description

  • Product name

    Recombinant Human STEAP4 protein (denatured)
  • Purity

    > 90 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMEKT CIDALPLTMN SSEKQETVCI FGTGDFGRSL GLKMLQCGYS VVFGSRNPQKTTLLPSGAEV LSYSEAAKKS GIIIIAIHRE HYDFLTELTE VLNGKILVDI SNNLKINQYP ESNAEYLAHL VPGAHVVKAF NTISAWALQS GALDASRQ
    • Predicted molecular weight

      21 kDa including tags
    • Amino acids

      1 to 152
    • Tags

      His-DDDDK tag N-Terminus
    • Additional sequence information

      NP_078912

Specifications

Our Abpromise guarantee covers the use of ab177658 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Information available upon request.

General Info

  • Alternative names

    • alpha-induced protein 9
    • Metalloreductase STEAP4
    • six transmembrane prostate protein 2
    • Six-transmembrane epithelial antigen of prostate 4
    • SixTransMembrane protein of prostate 2
    • STAMP 2
    • STAMP2
    • STEA4_HUMAN
    • STEAP 4
    • STEAP family member 4
    • STEAP4
    • TIARP
    • TNFAIP 9
    • TNFAIP9
    • Tumor necrosis factor
    • tumor necrosis factor, alpha-induced protein 9
    • tumor necrosis-alpha-induced adipose-related protein
    see all
  • Function

    Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Play a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.
  • Tissue specificity

    Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages.
  • Sequence similarities

    Belongs to the STEAP family.
    Contains 1 ferric oxidoreductase domain.
  • Cellular localization

    Cell membrane. Golgi apparatus membrane.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab177658 (3 µg).

References

ab177658 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab177658.
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