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Cell Biology Apoptosis Intracellular Kinases
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Recombinant Human STK3/MST-2 protein (ab159602)

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SDS-PAGE - Recombinant Human STK3/MST-2 protein (ab159602)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, WB

    Description

    • Product name

      Recombinant Human STK3/MST-2 protein
      See all STK3/MST-2 proteins and peptides
    • Expression system

      Wheat germ
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        DFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRH EEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTM
      • Amino acids

        253 to 350
      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab159602 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      Western blot

    • Form

      Liquid
    • Additional notes

      This product was previously labelled as STK3.

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • 0610042I06Rik
      • EC 2.7.11.1
      • FLJ90748
      • KB 1458E12.1
      • Kinase responsive to stress 1
      • KRS1
      • Mammalian STE20 like protein kinase 2
      • Mammalian STE20-like protein kinase 2
      • Mammalian sterile 20-like 2
      • Mess1
      • MST
      • MST-2
      • MST2
      • Mst3
      • Serine/threonine kinase 3
      • Serine/threonine kinase 3 (STE20 homolog, yeast)
      • Serine/threonine kinase 3 (Ste20, yeast homolog)
      • Serine/threonine protein kinase 3
      • Serine/threonine protein kinase Krs1
      • Serine/threonine-protein kinase 3
      • Serine/threonine-protein kinase Krs-1
      • STE20 like kinase MST2
      • STE20-like kinase MST2
      • Stk3
      • STK3_HUMAN
      • wu:fc19e11
      • zgc:55383
      see all
    • Function

      Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1.
    • Tissue specificity

      Expressed at high levels in adult kidney, skeletal and placenta tissues and at very low levels in adult heart, lung and brain tissues.
    • Sequence similarities

      Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
      Contains 1 protein kinase domain.
      Contains 1 SARAH domain.
    • Cellular localization

      Cytoplasm. Nucleus. The caspase-cleaved form cycles between nucleus and cytoplasm.
    • Target information above from: UniProt accession Q13188 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human STK3/MST-2 protein (ab159602)
      SDS-PAGE - Recombinant Human STK3/MST-2 protein (ab159602)
      ab159602 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab159602? Please let us know so that we can cite the reference in this datasheet.

    ab159602 has not yet been referenced specifically in any publications.

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