Overview

  • Product name
    Recombinant Human STXBP2 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDI LAEGITIVEDINKRREPIPSLEAIYLLSPTEKALIKDFQGTPTFTYKAAH IFFTDTCPEPLFSELGRSRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHST YNLYCPFRAEERTRQLEVLAQQIATLCATLQEYPAIRYRKGPEDTAQLAH AVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPVSPLLHELTFQAMA YDLLDIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHIADVSKKV TELLRTFCESKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHLHLADDC MKHFKGSVEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDK IRVLLLYILLRNGVSEENLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGG SGTSSRLEPRERMEPTYQLSRWTPVIKDVMEDAVEDRLDRNLWPFVSDPA PTASSQAAVSARFGHWHKNKAGIEARAGPRLIVYVMGGVAMSEMRAAYEV TRATEGKWEVLIGSSHILTPTRFLDDLKALDKKLEDIALP
    • Amino acids
      1 to 590
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab159608 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • FHL5
    • Hunc18b
    • MUNC18 2
    • pp10122
    • Protein unc-18 homolog 2
    • Protein unc-18 homolog B
    • STXB2_HUMAN
    • Stxbp2
    • syntaxin binding protein 2
    • Syntaxin-binding protein 2
    • Unc-18B
    • UNC18 2
    • Unc18-2
    • UNC18B
    see all
  • Function
    Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.
  • Tissue specificity
    Placenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes.
  • Involvement in disease
    Defects in STXBP2 are the cause of hemophagocytic lymphohistiocytosis familial type 5 (FHL5) [MIM:613101]. FHL5 is rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.
  • Sequence similarities
    Belongs to the STXBP/unc-18/SEC1 family.
  • Information by UniProt

Images

  • ab159608 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab159608 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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