Overview

Description

  • Nature

    Recombinant
  • Source

    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      67 kDa including tags
    • Amino acids

      58 to 422

Associated products

Specifications

Our Abpromise guarantee covers the use of ab125536 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • Purity

    > 70 % Densitometry.
    Purity determined to be >70% by densitometry.
  • Form

    Liquid
  • Additional notes

     This product was previously labelled as Styk1

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.29% Sodium chloride

General Info

  • Alternative names

    • DKFZp761P1010
    • NOK
    • Novel oncogene with kinase domain
    • Protein kinase STYK1
    • Protein PK unique
    • Protein PK-unique
    • Serine/threonine/tyrosine kinase 1
    • Styk 1
    • STYK1
    • STYK1_HUMAN
    • SuRTK 106
    • SuRTK106
    • Tyrosine protein kinase STYK1
    • Tyrosine-protein kinase STYK1
    see all
  • Function

    Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways.
  • Tissue specificity

    Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells LO2, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K562, but not in other tumor cells such as epidermoid carcinoma (A431). Undetectable in most normal lung tissues, widely expressed in lung cancers.
  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family.
    Contains 1 protein kinase domain.
  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • SDS-PAGE analysis of ab125536.

References

ab125536 has not yet been referenced specifically in any publications.

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