Overview

  • Product name

    Recombinant Human SUMO4 protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MANEKPTEEV KTENNNHINL KVAGQDGSVV QFKIKRQTPL SKLMKAYCEP RGLSMKQIRF RFGGQPISGT DKPAQLEMED EDTIDVFQQP TGGVY
    • Molecular weight

      13 kDa including tags
    • Amino acids

      1 to 93

Specifications

Our Abpromise guarantee covers the use of ab157025 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Purity

    > 90 % SDS-PAGE.

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.48% HEPES

General Info

  • Alternative names

    • dJ281H8.4
    • IDDM5
    • Small ubiquitin like modifier 4 protein
    • Small ubiquitin-like protein 4
    • Small ubiquitin-related modifier 4
    • SMT3 suppressor of mif two 3 homolog 2
    • SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)
    • SMT3H4
    • SUMO 4
    • SUMO-4
    • SUMO4
    • SUMO4_HUMAN
    see all
  • Function

    Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.
  • Tissue specificity

    Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.
  • Sequence similarities

    Belongs to the ubiquitin family. SUMO subfamily.
    Contains 1 ubiquitin-like domain.
  • Post-translational
    modifications

    In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates.
  • Information by UniProt

Images

  • SDS-PAGE analysis of ab157025 (1.5 µg), stained with coomassie blue.

References

ab157025 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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