Product nameRecombinant Human Superoxide Dismutase 1 protein
See all Superoxide Dismutase 1 proteins and peptides
Protein lengthFull length protein
Amino Acid Sequence
SequenceHHHHHHATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHG FHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGV ADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRL ACGVIGIAQ
Molecular weight16 kDa
Amino acids2 to 154
TagsHis tag C-Terminus
- Anti-Superoxide Dismutase 1 antibody (ab13498)
- Anti-Superoxide Dismutase 1 antibody (ab13499)
- Anti-Superoxide Dismutase 1 antibody (ab16831)
- Anti-6X His tag® antibody [HIS.H8] (ab18184)
- Anti-6X His tag® antibody [4D11] (ab5000)
- Anti-Superoxide Dismutase 1 antibody [EP1727Y] (ab51254)
- Anti-Superoxide Dismutase 1 antibody (ab52950)
- Anti-Superoxide Dismutase 1 antibody (ab62800)
- Anti-Superoxide Dismutase 1 antibody [EPR1726] (ab79390)
- Anti-6X His tag® antibody (ab9108)
Our Abpromise guarantee covers the use of ab153789 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Endotoxin level< 1.000 Eu/µg
Purity> 95 % SDS-PAGE.
Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Supplied as a 0.2 µM filtered solution.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride
- Amyotrophic lateral sclerosis 1 adult
FunctionDestroys radicals which are normally produced within the cells and which are toxic to biological systems.
Involvement in diseaseDefects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:105400]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.
Sequence similaritiesBelongs to the Cu-Zn superoxide dismutase family.
modificationsUnlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation. The pathogenic variants ALS1 Arg-86 and Ala-94 are ubiquitinated by MARCH5 leading to their proteasomal degradation.
The ditryptophan cross-link at Trp-33 is reponsible for the non-disulfide-linked homodimerization. Such modification might only occur in extreme conditions and additional experimental evidence is required.
Cellular localizationCytoplasm. The pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria.
- Information by UniProt
ab153789 has not yet been referenced specifically in any publications.