Recombinant Human SV2A protein (ab153025)

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Overview

Description

  • Nature

    Recombinant

  • Source

    Wheat germ
  • Amino Acid Sequence

    • Species

      Human

    • Sequence

      HLQAVDYASRTKVFPGERVGHVTFNFTLENQIHRGGQYFNDKFIGLRLKS VSFEDSL

    • Amino acids

      474 to 530

    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab153025 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form

    Liquid

  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • KIAA0736
    • OTTHUMP00000014065
    • SV2
    • Sv2a
    • SV2A_HUMAN
    • Synaptic vesicle glycoprotein 2
    • Synaptic vesicle glycoprotein 2A
    • Synaptic vesicle protein 2a
    see all

  • Function

    Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.

  • Sequence similarities

    Belongs to the major facilitator superfamily.

  • Post-translational
    modifications

    Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1.
    N-glycosylated.

  • Cellular localization

    Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human SV2A protein (ab153025)
    SDS-PAGE - Recombinant Human SV2A protein (ab153025)
    ab153025 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab153025 has not yet been referenced specifically in any publications.

Publishing research using ab153025? Please let us know so that we can cite the reference in this datasheet.

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