Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMAILFAV VARGTTILAK HAWCGGNFLE VTEQILAKIP SENNKLTYSH GNYLFHYICQ DRIVYLCITD DDFERSRAFN FLNEIKKRFQ TTYGSRAQTA LPYAMNSEFS SVLAAQLKHH SENKGLDKVM ETQAQVDELK GIMVRNIDLV AQRGERLELL IDKTENLVDS SVTFKTTSRN LARAMCMKNL K
    • Molecular weight

      23 kDa including tags
    • Amino acids

      1 to 188
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab131706 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF
  • Purity

    > 90 % SDS-PAGE.
    ab131706 is purified using conventional chromatography techniques
  • Form

    Liquid
  • Additional notes

    Previously labelled as SYBL1. 

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 20% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names

    • FLJ53045
    • FLJ53762
    • FLJ54296
    • HGNC:11486
    • OTTHUMP00000024258
    • OTTHUMP00000024259
    • OTTHUMP00000225953
    • SYBL 1
    • SYBL1
    • Synaptobrevin like 1
    • Synaptobrevin-like protein 1
    • Tetanus insensitive VAMP
    • Tetanus neurotoxin insensitive VAMP
    • Tetanus-insensitive VAMP
    • TI VAMP
    • Ti-VAMP
    • TIVAMP
    • VAMP-7
    • VAMP7
    • VAMP7_HUMAN
    • Vesicle-associated membrane protein 7
    see all
  • Function

    Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.
  • Tissue specificity

    Detected in all tissues tested.
  • Sequence similarities

    Belongs to the synaptobrevin family.
    Contains 1 longin domain.
    Contains 1 v-SNARE coiled-coil homology domain.
  • Cellular localization

    Cytoplasmic vesicle > secretory vesicle membrane. Golgi apparatus > trans-Golgi network membrane. Late endosome membrane. Lysosome membrane. Endoplasmic reticulum membrane. Cytoplasmic vesicle > phagosome membrane.
  • Information by UniProt

Images

  • 15% SDS-PAGE showing ab131706 at approximately 23.0 kDa (3µg).

References

ab131706 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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