Description

  • Product name

    Recombinant Human Syntaxin 1a protein
    See all Syntaxin 1a proteins and peptides
  • Purity

    > 95 % SDS-PAGE.
    Purified by conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MKDRTQELRTAKDSDDDDDVAVTVDRDRFMDEFFEQVEEIRGFIDKIAEN VEEVKRKHSAILASPNPDEKTKEELEELMSDIKKTANKVRSKLKSIEQSI EQEEGLNRSSADLRIRKTQHSTLSRKFVEVMSEYNATQSDYRERCKGRIQ RQLEITGRTTTSEELEDMLESGNPAIFASGIIMDSSISKQALSEIETRHS EIIKLENSIRELHDMFMDMAMLVESQGEMIDRIEYNVEHAVDYVERAVSD TKKAVKYQSKARRKK
    • Predicted molecular weight

      31 kDa
    • Amino acids

      1 to 265

Associated products

Specifications

Our Abpromise guarantee covers the use of ab222355 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.4
    Constituents: 0.02% DTT, 10% Glycerol, PBS

General Info

  • Alternative names

    • HPC 1
    • Neuron specific antigen HPC1
    • Neuron-specific antigen HPC-1
    • OTTHUMP00000174615
    • OTTHUMP00000174616
    • OTTHUMP00000174617
    • OTTHUMP00000174618
    • P35-1
    • STX1
    • STX1A
    • STX1A_HUMAN
    • SYN1A
    • Syntaxin 1A (brain)
    • Syntaxin 1A brain
    • Syntaxin-1A
    see all
  • Function

    Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
  • Tissue specificity

    Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.
  • Involvement in disease

    Note=STX1A is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
  • Sequence similarities

    Belongs to the syntaxin family.
    Contains 1 t-SNARE coiled-coil homology domain.
  • Cellular localization

    Secreted and Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cell junction > synapse > synaptosome.
  • Information by UniProt

Images

  • Recombinant human Syntaxin 1a (3μg) analysed by 15% SDS-PAGE.

References

ab222355 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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