Recombinant Human Syntenin protein (ab185832)

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Description

  • Product name

    Recombinant Human Syntenin protein
    See all Syntenin proteins and peptides

  • Purity

    > 95 % SDS-PAGE.
    Purity is determined by SEC-HPLC and reducing SDS-PAGE.

  • Endotoxin level

    < 1.000 Eu/µg

  • Expression system

    Escherichia coli

  • Accession

    O00560

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      SLYPSLEDLKVDKVIQAQTAFSANPANPAILSEASAPIPHDGNLYPRLYP ELSQYMGLSLNEEEIRANVAVVSGAPLQGQLVARPSSINYMVAPVTGNDV GIRRAEIKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPASLVG LRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTITM HKDSTGHVGFIFKNGKITSIVKDSSAARNGLLTEHNICEINGQNVIGLKD SQIADILSTSGTVVTITIMPAFIFEHIIKRMAPSIMKSLMDHTIPEVLEH HHHHH

    • Predicted molecular weight

      33 kDa including tags

    • Amino acids

      2 to 298

    • Tags

      His tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab185832 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    HPLC

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituent: 100% PBS

General Info

  • Alternative names

    • MDA-9
    • MDA9
    • Melanoma differentiation-associated protein 9
    • Pro-TGF-alpha cytoplasmic domain-interacting protein 18
    • Scaffold protein Pbp1
    • SDCB1_HUMAN
    • SDCBP
    • ST1
    • SYCL
    • Syndecan binding protein (syntenin)
    • Syndecan binding protein 1
    • Syndecan-binding protein 1
    • Syntenin 1
    • Syntenin-1
    • TACIP18
    see all

  • Function

    Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.

  • Tissue specificity

    Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.

  • Sequence similarities

    Contains 2 PDZ (DHR) domains.

  • Post-translational
    modifications

    Phosphorylated on tyrosine residues.

  • Cellular localization

    Cell junction > focal adhesion. Cell junction > adherens junction. Cell membrane. Endoplasmic reticulum membrane. Nucleus. Melanosome. Cytoplasm > cytosol. Cytoplasm > cytoskeleton. Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt

References

ab185832 has not yet been referenced specifically in any publications.

Publishing research using ab185832? Please let us know so that we can cite the reference in this datasheet.

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