Description

  • Product name

    Recombinant Human TAB2 protein
    See all TAB2 proteins and peptides
  • Purity

    = 80 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      AIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDTEDDEGAQWNCTACTFL NHPALIRCEQCEMPRHF
    • Predicted molecular weight

      8 kDa
    • Amino acids

      627 to 693
    • Tags

      GST tag N-Terminus
    • Additional sequence information

      NM_015093.

Specifications

Our Abpromise guarantee covers the use of ab207983 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.

    Constituents: 0.24% Tris, 0.87% Sodium chloride, 0.02% Beta mercaptoethanol, 10% Glycerol

General Info

  • Alternative names

    • CHTD2
    • FLJ21885
    • KIAA0733
    • MAP3K7IP2
    • Mitogen activated protein kinase kinase kinase 7 interacting protein 2
    • Mitogen-activated protein kinase kinase kinase 7-interacting protein 2
    • OTTHUMP00000040125
    • TAB 2
    • TAB-2
    • Tab2
    • TAB2_HUMAN
    • TAK1 binding protein 2
    • TAK1-binding protein 2
    • TGF beta activated kinase 1/MAP3K7 binding protein 2
    • TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
    • TGF-beta-activated kinase 1-binding protein 2
    see all
  • Function

    Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.
  • Tissue specificity

    Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.
  • Involvement in disease

    Defects in TAB2 are the cause of congenital heart disease non-syndromic type 2 (CHTD2) [MIM:612863]. It is a disease characterized by congenital developmental abnormalities involving structures of the heart. Clinical features include left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and aortic dilation. Note=A chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation t(2;6)(q21;q25).
  • Sequence similarities

    Contains 1 CUE domain.
    Contains 1 RanBP2-type zinc finger.
  • Post-translational
    modifications

    Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation.
    Phosphorylated.
  • Cellular localization

    Membrane. Cytoplasm > cytosol. Following IL1 stimulation, translocation occurs from the membrane to cytosol.
  • Information by UniProt

Images

  • Coomassie stained SDS-PAGE analysis of 5 µg ab207983.

References

ab207983 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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