Recombinant Human TCEA1 protein (ab126676)

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Description

  • Product name

    Recombinant Human TCEA1 protein
    See all TCEA1 proteins and peptides

  • Purity

    > 90 % SDS-PAGE.
    ab126676 is purified using conventional chromatography techniques.

  • Expression system

    Escherichia coli

  • Accession

    P23193

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMEDEVV RFAKKMDKMV QKKNAAGALD LLKELKNIPM TLELLQSTRI GMSVNAIRKQ STDEEVTSLA KSLIKSWKKL LDGPSTEKDL DEKKKEPAIT SQNSPEAREE STSSGNVSNR KDETNARDTY VSSFPRAPST SDSVRLKCRE MLAAALRTGD DYIAIGADEE ELGSQIEEAI YQEIRNTDMK YKNRVRSRIS NLKDAKNPNL RKNVLCGNIP PDLFARMTAE EMASDELKEM RKNLTKEAIR EHQMAKTGGT QTDLFTCGKC KKKNCTYTQV QTRSADEPMT TFVVCNECGN RWKFC

    • Predicted molecular weight

      37 kDa including tags

    • Amino acids

      1 to 301

    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab126676 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.50
    Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol, 0.29% Sodium chloride

General Info

  • Alternative names

    • GTF2S
    • SII
    • TCEA
    • Tcea1
    • TCEA1_HUMAN
    • TF2S
    • TFIIS
    • Transcription elongation factor A (SII) 1
    • Transcription elongation factor A protein 1
    • Transcription elongation factor A, 1
    • Transcription elongation factor S-II protein 1
    • Transcription elongation factor TFIIS.o
    see all

  • Function

    Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.

  • Involvement in disease

    Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.

  • Sequence similarities

    Belongs to the TFS-II family.
    Contains 1 TFIIS central domain.
    Contains 1 TFIIS N-terminal domain.
    Contains 1 TFIIS-type zinc finger.

  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.

  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human TCEA1 protein (ab126676)
    SDS-PAGE - Recombinant Human TCEA1 protein (ab126676)
    15% SDS-PAGE analysis of ab126676 (3µg)

References

ab126676 has not yet been referenced specifically in any publications.

Publishing research using ab126676? Please let us know so that we can cite the reference in this datasheet.

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