Recombinant Human TCEA1 protein (ab126676)

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SDS-PAGE - Recombinant Human TCEA1 protein (ab126676)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 90% SDS-PAGE
    • Tags: His tag N-Terminus
    • Suitable for: SDS-PAGE, MS

    Description

    • Product name

      Recombinant Human TCEA1 protein
      See all TCEA1 proteins and peptides

    • Purity

      > 90 % SDS-PAGE.
      ab126676 is purified using conventional chromatography techniques.

    • Expression system

      Escherichia coli

    • Accession

      P23193

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MGSSHHHHHH SSGLVPRGSH MGSHMEDEVV RFAKKMDKMV QKKNAAGALD LLKELKNIPM TLELLQSTRI GMSVNAIRKQ STDEEVTSLA KSLIKSWKKL LDGPSTEKDL DEKKKEPAIT SQNSPEAREE STSSGNVSNR KDETNARDTY VSSFPRAPST SDSVRLKCRE MLAAALRTGD DYIAIGADEE ELGSQIEEAI YQEIRNTDMK YKNRVRSRIS NLKDAKNPNL RKNVLCGNIP PDLFARMTAE EMASDELKEM RKNLTKEAIR EHQMAKTGGT QTDLFTCGKC KKKNCTYTQV QTRSADEPMT TFVVCNECGN RWKFC

      • Predicted molecular weight

        37 kDa including tags

      • Amino acids

        1 to 301

      • Tags

        His tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab126676 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      Mass Spectrometry

    • Mass spectrometry

      MALDI-TOF

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 7.50
      Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol (glycerin, glycerine), 0.29% Sodium chloride

    General Info

    • Alternative names

      • GTF2S
      • SII
      • TCEA
      • Tcea1
      • TCEA1_HUMAN
      • TF2S
      • TFIIS
      • Transcription elongation factor A (SII) 1
      • Transcription elongation factor A protein 1
      • Transcription elongation factor A, 1
      • Transcription elongation factor S-II protein 1
      • Transcription elongation factor TFIIS.o
      see all

    • Function

      Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.

    • Involvement in disease

      Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.

    • Sequence similarities

      Belongs to the TFS-II family.
      Contains 1 TFIIS central domain.
      Contains 1 TFIIS N-terminal domain.
      Contains 1 TFIIS-type zinc finger.

    • Post-translational
      modifications

      Phosphorylated upon DNA damage, probably by ATM or ATR.

    • Cellular localization

      Nucleus.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human TCEA1 protein (ab126676)
      SDS-PAGE - Recombinant Human TCEA1 protein (ab126676)
      15% SDS-PAGE analysis of ab126676 (3µg)

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab126676? Please let us know so that we can cite the reference in this datasheet.

    ab126676 has not yet been referenced specifically in any publications.

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