Recombinant Human TCF7 protein (ab159646)

Our Abpromise guarantee covers the use of ab159646 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Alternative names
- FLJ36364
- MGC47735
- OTTHUMP00000159391
- T cell factor 1
- T cell specific transcription factor 1
- T-cell factor 1
- T-cell-specific transcription factor 1
- TCF-1
- TCF-7
- TCF1
- Tcf7
- TCF7 transcription factor 7
- TCF7_HUMAN
- Transcription factor 7
- Transcription factor 7 (T cell specific HMG box)
- Transcription factor-7, T-cell specific
- Transcription factor-7, T-cell specific, 1
see all
Function

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
Tissue specificity

Predominantly in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.
Sequence similarities

Belongs to the TCF/LEF family.
Contains 1 HMG box DNA-binding domain.
Cellular localization

Nucleus.
Target information above from: UniProt accession P36402 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Human TCF7 protein (ab159646)

ab159646 on a 12.5% SDS-PAGE stained with Coomassie Blue.

ab159646 has not yet been referenced specifically in any publications.

Publishing research using ab159646? Please let us know so that we can cite the reference in this datasheet.

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