Description

  • Product name

    Recombinant Human Tcl1 protein
  • Purity

    > 90 % SDS-PAGE.
    Purified by using conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD

Associated products

Specifications

Our Abpromise guarantee covers the use of ab87690 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.79% Tris HCl, 10% Glycerol

General Info

  • Alternative names

    • Anti TCL1A
    • Lymphoma/leukemia, T-cell
    • Oncogene TCL-1
    • Oncogene TCL1
    • P14 TCL1
    • P14 TCL1 protein
    • Protein p14 TCL1
    • T cell leukemia 1
    • T cell lymphoma 1
    • T cell lymphoma 1A
    • T-cell leukemia/lymphoma 1A
    • T-cell leukemia/lymphoma protein 1A
    • TCL 1 protein
    • TCL1
    • TCL1 oncogene
    • TCL1 PEN
    • Tcl1a
    • TCL1A antibody
    • TCL1A_HUMAN
    see all
  • Function

    Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
  • Tissue specificity

    Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
  • Involvement in disease

    Note=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
  • Sequence similarities

    Belongs to the TCL1 family.
  • Cellular localization

    Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Microsomal fraction.
  • Information by UniProt

Images

  • ab87690 on 15% SDS-PAGE (3µg)

References

ab87690 has not yet been referenced specifically in any publications.

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