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    recombinant-human-tfe3-protein-ab152741.pdf

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Immunology Adaptive Immunity T Cells Non-CD
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Recombinant Human TFE3 protein (ab152741)

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SDS-PAGE - Recombinant Human TFE3 protein (ab152741)

    Key features and details

    • Expression system: Wheat germ
    • Suitable for: WB, SDS-PAGE, ELISA

    Description

    • Product name

      Recombinant Human TFE3 protein
    • Expression system

      Wheat germ
    • Accession

      P19532
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        RPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQA LTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIG
      • Predicted molecular weight

        36 kDa including tags
      • Amino acids

        166 to 254

    Specifications

    Our Abpromise guarantee covers the use of ab152741 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Western blot

      SDS-PAGE

      ELISA

    • Form

      Liquid
    • Additional notes

       

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • bHLH e33
      • bHLHe33
      • Class E basic helix-loop-helix protein 33
      • RCCP 2
      • RCCP2
      • RCCX1
      • Renal cell carcinoma, papillary
      • Tcfe 3
      • Tcfe3
      • TFE 3
      • Tfe3
      • TFE3_HUMAN
      • TFEA
      • Transcription factor binding to IGHM enhancer 3
      • Transcription factor E family, member A
      • Transcription factor E3
      • Transcription factor for IgH enhancer
      • Transcription factor for immunoglobulin heavy chain enhancer 3
      see all
    • Function

      Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site.
    • Tissue specificity

      Ubiquitous in fetal and adult tissues.
    • Involvement in disease

      Note=A chromosomal aberration involving TFE3 is found in patients with alveolar soft part sarcoma. Translocation t(X;17)(p11;q25) with ASPSCR1 forms a ASPSCR1-TFE3 fusion protein.
      Note=Chromosomal aberrations involving TFE3 are found in patients with papillary renal cell carcinoma. Translocation t(X;1)(p11.2;q21.2) with PRCC; translocation t(X;1)(p11.2;p34) with PSF; inversion inv(X)(p11.2;q12) that fuses NONO to TFE3.
    • Sequence similarities

      Belongs to the MiT/TFE family.
      Contains 1 basic helix-loop-helix (bHLH) domain.
    • Post-translational
      modifications

      Sumoylated; does not affect dimerization with MITF.
    • Cellular localization

      Nucleus.
    • Target information above from: UniProt accession P19532 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human TFE3 protein (ab152741)
      SDS-PAGE - Recombinant Human TFE3 protein (ab152741)
      12.5% SDS-PAGE analysis of ab152741 stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab152741? Please let us know so that we can cite the reference in this datasheet.

    ab152741 has not yet been referenced specifically in any publications.

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