Overview

  • Product name
    Recombinant Human TFE3 protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
      P19532
    • Species
      Human
    • Sequence
      RPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQA LTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIG
    • Molecular weight
      36 kDa including tags
    • Amino acids
      166 to 254

Specifications

Our Abpromise guarantee covers the use of ab152741 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • bHLH e33
    • bHLHe33
    • Class E basic helix-loop-helix protein 33
    • RCCP 2
    • RCCP2
    • RCCX1
    • Renal cell carcinoma, papillary
    • Tcfe 3
    • Tcfe3
    • TFE 3
    • Tfe3
    • TFE3_HUMAN
    • TFEA
    • Transcription factor binding to IGHM enhancer 3
    • Transcription factor E family, member A
    • Transcription factor E3
    • Transcription factor for IgH enhancer
    • Transcription factor for immunoglobulin heavy chain enhancer 3
    see all
  • Function
    Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site.
  • Tissue specificity
    Ubiquitous in fetal and adult tissues.
  • Involvement in disease
    Note=A chromosomal aberration involving TFE3 is found in patients with alveolar soft part sarcoma. Translocation t(X;17)(p11;q25) with ASPSCR1 forms a ASPSCR1-TFE3 fusion protein.
    Note=Chromosomal aberrations involving TFE3 are found in patients with papillary renal cell carcinoma. Translocation t(X;1)(p11.2;q21.2) with PRCC; translocation t(X;1)(p11.2;p34) with PSF; inversion inv(X)(p11.2;q12) that fuses NONO to TFE3.
  • Sequence similarities
    Belongs to the MiT/TFE family.
    Contains 1 basic helix-loop-helix (bHLH) domain.
  • Post-translational
    modifications
    Sumoylated; does not affect dimerization with MITF.
  • Cellular localization
    Nucleus.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human TFE3 protein (ab152741)
    SDS-PAGE - Recombinant Human TFE3 protein (ab152741)
    12.5% SDS-PAGE analysis of ab152741 stained with Coomassie Blue.

References

ab152741 has not yet been referenced specifically in any publications.

Publishing research using ab152741? Please let us know so that we can cite the reference in this datasheet.

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