Recombinant Human TGF beta 2 protein (ab159690)

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Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKL TSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYA KEVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFR VFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLS FDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARF AGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRK KRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGAC PYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI EQLSNMIVKSCKCS
    • Molecular weight
      74 kDa including tags
    • Amino acids
      1 to 414
    • Tags
      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab159690 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • BSC-1 cell growth inhibitor
    • BSC1 cell growth inhibitor
    • Cetermin
    • G-TSF
    • Glioblastoma-derived T-cell suppressor factor
    • GTSF
    • LAP
    • Latency-associated peptide
    • MGC116892
    • MGF
    • Milk growth factor
    • Polyergin
    • TGF-beta-2
    • TGF-beta2
    • TGFB2
    • TGFB2_HUMAN
    • Transforming growth factor beta 2
    see all
  • Function
    TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.
  • Involvement in disease
    A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9.
    Loeys-Dietz syndrome 4
    Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD). NSAD is a frequently asymptomatic but potentially lethal disease characterized by thoracic aortic aneurysms and dissections without additional syndromic features.
  • Sequence similarities
    Belongs to the TGF-beta family.
  • Post-translational
    modifications
    The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive.
  • Cellular localization
    Secreted.
  • Information by UniProt

Images

  • ab159690 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab159690 has not yet been referenced specifically in any publications.

Publishing research using ab159690? Please let us know so that we can cite the reference in this datasheet.

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