Product nameRecombinant Human Thioredoxin / TRX protein
See all Thioredoxin / TRX proteins and peptides
Purity> 95 % SDS-PAGE.
Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Endotoxin level1.000 Eu/µg
Expression systemEscherichia coli
Protein lengthFull length protein
SequenceMGSSHHHHHHSSGLVPRGSHMVKQIESKTAFQEALDAAGDKLVVVDFSAT WCGPCKMIKPFFHSL SEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKE KLEATINELV
Predicted molecular weight12 kDa
Amino acids1 to 105
TagsHis tag N-Terminus
- Anti-Thioredoxin / TRX antibody [EPR6111] (ab109385)
- Anti-Thioredoxin / TRX antibody (ab115758)
- Anti-Thioredoxin / TRX antibody [EPR6110] (ab133524)
- Anti-Thioredoxin / TRX antibody [3A1] (ab16965)
- Anti-6X His tag® antibody [HIS.H8] (ab18184)
- Anti-Thioredoxin / TRX antibody (ab26320)
- Anti-6X His tag® antibody [4D11] (ab5000)
- Anti-Thioredoxin / TRX antibody (ab86255)
- Anti-6X His tag® antibody (ab9108)
Our Abpromise guarantee covers the use of ab172159 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on Dry Ice. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Constituent: 100% PBS
Supplied as a 0.2 µM filtered solution.
- ATL derived factor
- ATL-derived factor
FunctionParticipates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
Sequence similaritiesBelongs to the thioredoxin family.
Contains 1 thioredoxin domain.
modificationsIn the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins.
In case of infection, ubiquitinated by S.typhimurium protein slrP, leading to its degradation.
Cellular localizationNucleus. Cytoplasm. Secreted. Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus.
- Information by UniProt
ab172159 has not yet been referenced specifically in any publications.