Product nameRecombinant Human Thyroid Hormone Receptor beta protein
See all Thyroid Hormone Receptor beta proteins and peptides
Protein lengthFull length protein
Amino Acid Sequence
SequenceMASMTGGQQMGRGHHHHHHGNLYFQGGEFELTPNSMTENGLTAWDKPKHC PDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHL DHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCI YVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE LIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFS HFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVR YDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEV ALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
Amino acids2 to 461
TagsHis tag N-Terminus
- Anti-Thyroid Hormone Receptor beta antibody (ab106813)
- Anti-Thyroid Hormone Receptor beta antibody (ab15545)
- Anti-6X His tag® antibody [HIS.H8] (ab18184)
- Anti-6X His tag® antibody [4D11] (ab5000)
- Anti-Thyroid Hormone Receptor beta antibody (ab53170)
- Anti-Thyroid Hormone Receptor beta antibody - ChIP Grade (ab5622)
- Anti-6X His tag® antibody (ab9108)
- Anti-T7 tag® antibody (ab9115)
Our Abpromise guarantee covers the use of ab134854 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Purity> 90 % SDS-PAGE.
ab134854 was expressed in E. coli as inclusion bodies, refolded and chromatographically purified.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 0.05% DTT, 0.32% Tris HCl, 0.02% EDTA, 3.4% DL-Arginine
Buffer also contains a proprietary formulation of NaCl, KCl and Glycerol.
- Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2
- C ERBA 2
- C ERBA BETA
FunctionHigh affinity receptor for triiodothyronine.
Involvement in diseaseDefects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also known as familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.
Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
- Information by UniProt
ab134854 has not yet been referenced specifically in any publications.