Recombinant Human TICAM2 protein (ab123160)

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SDS-PAGE - Recombinant Human TICAM2 protein (ab123160)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 85% SDS-PAGE
    • Tags: His tag N-Terminus
    • Suitable for: SDS-PAGE, MS

    Description

    • Product name

      Recombinant Human TICAM2 protein

    • Purity

      > 85 % SDS-PAGE.
      ab123160 was purified using conventional chromatography techniques and is >85% pure by SDS PAGE.

    • Expression system

      Escherichia coli

    • Accession

      Q86XR7

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MGSSHHHHHH SSGLVPRGSH MGSHMGIGKS KINSCPLSLS WGKRHSVDTS PGYHESDSKK SEDLSLCNVA EHSNTTEGPT GKQEGAQSVE EMFEEEAEEE VFLKFVILHA EDDTDEALRV QNLLQDDFGI KPGIIFAEMP CGRQHLQNLD DAVNGSAWTI LLLTENFLRD TWCNFQFYTS LMNSVNRQHK YNSVIPMRPL NNPLPRERTP FALQTINALE EESRGFPTQV ERIFQESVYK TQQTIWKETR NMVQRQFIA

      • Predicted molecular weight

        29 kDa including tags

      • Amino acids

        1 to 235

      • Tags

        His tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab123160 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      Mass Spectrometry

    • Mass spectrometry

      MALDI-TOF

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 8.00
      Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride

    General Info

    • Alternative names

      • Putative NF-kappa-B-activating protein 502
      • TCAM2_HUMAN
      • TICAM-2
      • TICAM2
      • TIR containing adapter molecule 2
      • TIR domain containing adaptor protein
      • TIR domain-containing adapter molecule 2
      • TIRAP 3
      • TIRAP3
      • TIRAP3a short form
      • TIRP
      • Toll-like receptor adaptor protein 3
      • Toll/interleukin-1 receptor domain-containing protein
      • TRAM
      • TRIF-related adapter molecule
      see all

    • Function

      Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1.

    • Tissue specificity

      Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas.

    • Sequence similarities

      Contains 1 TIR domain.

    • Domain

      The TIR domain mediates the interaction with TRAF6.

    • Post-translational
      modifications

      Phosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.
      Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.

    • Cellular localization

      Cytoplasm. Golgi apparatus. Cell membrane. Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human TICAM2 protein (ab123160)
      SDS-PAGE - Recombinant Human TICAM2 protein (ab123160)

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab123160? Please let us know so that we can cite the reference in this datasheet.

    ab123160 has not yet been referenced specifically in any publications.

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