Description

  • Product name

    Recombinant human TIM 4 protein (Fc Chimera Active)
    See all TIM 4 proteins and peptides
  • Biological activity

    Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.

  • Purity

    > 98 % SDS-PAGE.

  • Endotoxin level

    < 5.000 Eu/mg
  • Expression system

    HEK 293 cells
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      ETVVTEVLGHRVTLPCLYSSWSHNSNSMCWGKDQCPYSGCKEALIRTDGM RVTSRKSAKYRLQGTIPRGDVSLTILNPSESDSGVYCCRIEVPGWFNDVK INVRLNLQRASTTTHRTATTTTRRTTTTSPTTTRQMTTTPAALPTTVVTT PDLTTGTPLQMTTIAVFTTANTCLSLTPSTLPEEATGLLTPEPSKEGPIL TAESETVLPSDSWSSVESTSADTVLLTSKESKVWDLPSTSHVSMWKTSDS VSSPQPGASDTAVPEQNKTTKTGQMDGIPMSMKNEMPISQL
    • Predicted molecular weight

      80 kDa including tags
    • Amino acids

      25 to 315
    • Additional sequence information

      Fused to the N-terminus of the Fc region of mouse IgG2a.

Specifications

Our Abpromise guarantee covers the use of ab214961 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C long term. Avoid freeze / thaw cycle.

    Constituent: 100% PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Reconstitute with 100 µL sterile water. Add 1X PBS to the desired protein concentration. Working aliquots are stable for up to 3 months when stored at -20°C.

General Info

  • Alternative names

    • SMUCKLER
    • Spleen, mucin-containing, knockout of lymphotoxin protein
    • T cell immunoglobulin and mucin domain containing protein 4
    • T-cell immunoglobulin and mucin domain containing 4
    • T-cell immunoglobulin and mucin domain containing molecule
    • T-cell immunoglobulin and mucin domain-containing protein 4
    • T-cell immunoglobulin and mucin domains-containing protein 4
    • T-cell membrane protein 4
    • TIM-4
    • Tim4
    • TIMD 4
    • TIMD-4
    • Timd4
    • TIMD4_HUMAN
    see all
  • Function

    Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. TIM family.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Domain

    Recognizes phosphatidyl serine via its immunoglobulin domain.
  • Cellular localization

    Membrane.
  • Information by UniProt

References

ab214961 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab214961.
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