Overview

Description

  • Nature

    Recombinant
  • Source

    CHO cells
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      ETVVTE VLGHRVTLPC LYSSWSHNSN SMCWGKDQCP YSGCKEALIR TDGMRVTSRK SAKYRLQGTI PRGDVSLTIL NPSESDSGVY CCRIEVPGWF NDVKINVRLN LQRASTTTHR TATTTTRRTT TTSPTTTRQM TTTPAALPTT VVTTPDLTTG TPLQMTTIAV FTTANTCLSL TPSTLPEEAT GLLTPEPSKE GPILTAESET VLPSDSWSSV ESTSADTVLL TSKESKVWDL PSTSHVSMWK TSDSVSSPQP GASDTAVPEQ NKTTKTGQMD GIPMSMKNEM PISQL
    • Molecular weight

      31 kDa
    • Amino acids

      25 to 315
    • Additional sequence information

      Extracellular domain fused to the N-terminus of the Fc region of Human IgG1.

Associated products

Specifications

Our Abpromise guarantee covers the use of ab216249 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.

  • Applications

    Functional Studies

    SDS-PAGE

  • Endotoxin level

    < 0.060 Eu/µg
  • Purity

    >= 98 % SDS-PAGE.

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C long term. Avoid freeze / thaw cycle.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Reconstitute with 100 µl sterile water. Add 1X PBS to the desired protein concentration.

General Info

  • Alternative names

    • SMUCKLER
    • Spleen, mucin-containing, knockout of lymphotoxin protein
    • T cell immunoglobulin and mucin domain containing protein 4
    • T-cell immunoglobulin and mucin domain containing 4
    • T-cell immunoglobulin and mucin domain containing molecule
    • T-cell immunoglobulin and mucin domain-containing protein 4
    • T-cell immunoglobulin and mucin domains-containing protein 4
    • T-cell membrane protein 4
    • TIM-4
    • Tim4
    • TIMD 4
    • TIMD-4
    • Timd4
    • TIMD4_HUMAN
    see all
  • Function

    Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. TIM family.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Domain

    Recognizes phosphatidyl serine via its immunoglobulin domain.
  • Cellular localization

    Membrane.
  • Information by UniProt

References

ab216249 has not yet been referenced specifically in any publications.

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