Overview

  • Product name
    Recombinant Human TIPE2 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYT HSRPQAQRVIKDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMT ALSFGEVDFTFEAAVLAGLLTECRDVLLELVEHHLTPKSHGRIRHVFDHF SDPGLLTALYGPDFTQHLGKICDGLRKLLDEGKL
    • Amino acids
      1 to 184
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab164054 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.

    Protein previously known as Tumor necrosis factor alpha-induced protein 8-like protein 2.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • AW610835
    • FLJ23467
    • Inflammation factor 20
    • Inflammation factor protein 20
    • TIPE2
    • TNF alpha-induced protein 8-like protein 2
    • TNFAIP8-like protein 2
    • TNFAIP8L2
    • TP8L2_HUMAN
    • Tumor necrosis factor alpha induced protein 8 like 2
    • Tumor necrosis factor alpha-induced protein 8-like protein 2
    see all
  • Function
    Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.
  • Sequence similarities
    Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
  • Domain
    The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human TIPE2 protein (ab164054)
    SDS-PAGE - Recombinant Human TIPE2 protein (ab164054)
    ab164054 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab164054 has not yet been referenced specifically in any publications.

Publishing research using ab164054? Please let us know so that we can cite the reference in this datasheet.

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