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    recombinant-human-tlr2-protein-ab159715.pdf

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Immunology Innate Immunity Macrophage / Inflamm.
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Recombinant Human TLR2 protein (ab159715)

  • Datasheet
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SDS-PAGE - Recombinant Human TLR2 protein (ab159715)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, WB

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    Description

    • Product name

      Recombinant Human TLR2 protein
      See all TLR2 proteins and peptides
    • Expression system

      Wheat germ
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        KPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDF AGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDV
      • Amino acids

        121 to 220
      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab159715 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      Western blot

    • Form

      Liquid
    • Additional notes

       

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • CD282
      • CD282 antigen
      • TIL 4
      • TIL4
      • TLR 2
      • TLR2
      • TLR2_HUMAN
      • Toll like receptor 2
      • Toll like receptor 2 precursor
      • Toll-like receptor 2
      • Toll/interleukin 1 receptor like 4
      • Toll/interleukin 1 receptor like protein 4
      • Toll/interleukin receptor like protein 4
      • Toll/interleukin-1 receptor-like protein 4
      see all
    • Function

      Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
    • Tissue specificity

      Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
    • Sequence similarities

      Belongs to the Toll-like receptor family.
      Contains 14 LRR (leucine-rich) repeats.
      Contains 1 TIR domain.
    • Post-translational
      modifications

      Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
    • Cellular localization

      Membrane.
    • Target information above from: UniProt accession O60603 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human TLR2 protein (ab159715)
      SDS-PAGE - Recombinant Human TLR2 protein (ab159715)
      ab159715 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download

    References (0)

    Publishing research using ab159715? Please let us know so that we can cite the reference in this datasheet.

    ab159715 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a question

    Question

    Product code: 159715
    Inquiry: I would like to know if your proprietary TAG is an HIS tag. Thanks in advance

    Read More

    Abcam community

    Verified customer

    Asked on Feb 21 2017

    Answer

    There is GST tag at the N-terminus.

    Read More

    Abcam Scientific Support

    Answered on Feb 21 2017

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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