Recombinant Human TLR7 protein (ab153341)

Submit an Abreview Q&A (1)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
      Q9NYK1
    • Species
      Human
    • Sequence
      ARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINH IPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGL
    • Molecular weight
      37 kDa including tags
    • Amino acids
      27 to 126
    • Tags
      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab153341 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • PRO285
    • TLR 7
    • Tlr7
    • TLR7_HUMAN
    • Toll like receptor 7
    • Toll-like receptor 7
    • UNQ248
    see all
  • Function
    Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • Tissue specificity
    Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
  • Sequence similarities
    Belongs to the Toll-like receptor family.
    Contains 27 LRR (leucine-rich) repeats.
    Contains 1 TIR domain.
  • Cellular localization
    Endoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle > phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human TLR7 protein (ab153341)
    SDS-PAGE - Recombinant Human TLR7 protein (ab153341)
    ab153341 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab153341 has not yet been referenced specifically in any publications.

Publishing research using ab153341? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Submit a review Submit a question

1 Review or Q&A

10
Votes: Highest First

Is it possible for you to tell me the antibodies used to detect the proteins Human TLR7 protein fragment (ab153341) and Human TLR8 full length protein (ab153344) to generate the images displayed on your website?

Thank you for contacting us.

Actually, no antibody was used to create these images:

As the purified, recombinant tagged fragments/proteins were used, the gels could directly be stained with Coomassie.

Coomassie stains all p...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up