Recombinant human TNFAIP3 protein (ab157073)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      43 kDa

Specifications

Our Abpromise guarantee covers the use of ab157073 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Note: must be pre-incubated with 10mM DTT at room temperature for 15 minutes to activate the enzyme prior to running activity assays.
  • Applications

    Functional Studies

    SDS-PAGE

  • Purity
    >= 80 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.50
    Constituents: 0.08% DTT, 0.39% Tris HCl, 0.03% EDTA, 1.17% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • A20
    • AISBL
    • MGC104522
    • MGC138687
    • MGC138688
    • OTU domain containing protein 7C
    • OTU domain-containing protein 7C
    • OTUD7C
    • Putative DNA binding protein A20
    • Putative DNA-binding protein A20
    • TNAP3_HUMAN
    • TNF alpha-induced protein 3
    • TNFA1P2
    • TNFAIP 3
    • TNFAIP3
    • TNFAIP3 (A20)
    • Tumor necrosis factor alpha induced protein 3
    • Tumor necrosis factor alpha-induced protein 3
    • Tumor necrosis factor induced protein 3
    • Tumor necrosis factor inducible protein A20
    • tumor necrosis factor, alpha-induced protein 3
    • Zinc finger protein A20
    see all
  • Function
    Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. In vitro able to deubiquitinate both 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system.
  • Sequence similarities
    Belongs to the peptidase C64 family.
    Contains 7 A20-type zinc fingers.
    Contains 1 OTU domain.
  • Domain
    The A20-type zinc fingers mediate the ubiquitin ligase activity.
    The OTU domain mediates the deubiquitinase activity.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt

References

ab157073 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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