This product is an active protein and may elicit a biological response in vivo, handle with caution.
OTU domain containing protein 7C
OTU domain-containing protein 7C
Putative DNA binding protein A20
Putative DNA-binding protein A20
TNF alpha-induced protein 3
Tumor necrosis factor alpha induced protein 3
Tumor necrosis factor alpha-induced protein 3
Tumor necrosis factor induced protein 3
Tumor necrosis factor inducible protein A20
tumor necrosis factor, alpha-induced protein 3
Zinc finger protein A20
Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. In vitro able to deubiquitinate both 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system.
Belongs to the peptidase C64 family. Contains 7 A20-type zinc fingers. Contains 1 OTU domain.
The A20-type zinc fingers mediate the ubiquitin ligase activity. The OTU domain mediates the deubiquitinase activity.