Description

  • Product name

    Recombinant human Tnk1 protein (Active)
  • Biological activity

    The specific activity of ab207985 was determined to be 14 nmol/min/mg

  • Purity

    > 75 % Densitometry.

  • Expression system

    Baculovirus infected Sf9 cells
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      85 kDa including tags
    • Amino acids

      1 to 510
    • Tags

      GST tag N-Terminus
    • Additional sequence information

      NM_003985

Specifications

Our Abpromise guarantee covers the use of ab207985 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 7.50
    Constituents: 0.79% Tris HCl, 0.87% Sodium chloride, 0.003% EDTA, 0.004% DTT, 0.002% PMSF, 25% Glycerol

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • CD38 negative kinase 1
    • EC 2.7.10.2
    • Kinase of embryonic stem cells
    • Kos 1
    • Kos1
    • MGC46193
    • Non receptor tyrosine protein kinase TNK 1
    • Non receptor tyrosine protein kinase TNK1
    • Non-receptor tyrosine-protein kinase TNK1
    • Tnk 1
    • Tnk1
    • TNK1_HUMAN
    • Tyrosine kinase non receptor 1
    see all
  • Function

    Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.
  • Tissue specificity

    Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain.
  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family.
    Contains 1 protein kinase domain.
    Contains 1 SH3 domain.
  • Post-translational
    modifications

    Autophosphorylated on tyrosine residues.
  • Cellular localization

    Cytoplasm. Membrane.
  • Information by UniProt

Images

  • The specific activity of Tnk1 (ab207985) was determined to be 38 nmol/min/mg as per activity assay protocol and was equivalent to 15 nmol/min/mg as per radiometric assay
  • SDS PAGE analysis of ab207985
  • SDS PAGE analysis of ab207985
  • Kinase Assay demonstrating specific activity of ab207985

  • SDS-PAGE showing ab207985

References

ab207985 has not yet been referenced specifically in any publications.

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