The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
RNA polymerase I termination factor
Transcription termination factor 1
Transcription termination factor I
Transcription termination factor RNA polymerase I
Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.
Contains 2 Myb-like domains.
The N-terminal region (NRD) inhibits DNA-binding via its interaction with the C-terminal region.
Phosphorylated upon DNA damage, probably by ATM or ATR.