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Cardiovascular Blood Serum Proteins
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Recombinant Human Transferrin Receptor protein (ab159687)

  • Datasheet
  • SDS
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SDS-PAGE - Recombinant Human Transferrin Receptor protein (ab159687)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, WB

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    Description

    • Product name

      Recombinant Human Transferrin Receptor protein
      See all Transferrin Receptor proteins and peptides
    • Expression system

      Wheat germ
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        YGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFP AARRLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLAL Y
      • Amino acids

        68 to 168
      • Tags

        GST tag N-Terminus

    Associated products

      Specifications

      Our Abpromise guarantee covers the use of ab159687 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      • Applications

        ELISA

        Western blot

      • Form

        Liquid
      • Additional notes

         

         

      • Concentration information loading...

      Preparation and Storage

      • Stability and Storage

        Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

        pH: 8.00
        Constituents: 0.31% Glutathione, 0.79% Tris HCl

      General Info

      • Alternative names

        • CD 71
        • CD71
        • CD71 antigen
        • IMD46
        • OTTHUMP00000208523
        • OTTHUMP00000208524
        • OTTHUMP00000208525
        • p90
        • sTfR
        • T9
        • TfR
        • TFR 1
        • TfR1
        • TFR1_HUMAN
        • TFRC
        • TR
        • Transferrin receptor (p90 CD71)
        • Transferrin receptor protein 1, serum form
        • Trfr
        see all
      • Function

        Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
        (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
      • Involvement in disease

        Immunodeficiency 46
      • Sequence similarities

        Belongs to the peptidase M28 family. M28B subfamily.
        Contains 1 PA (protease associated) domain.
      • Post-translational
        modifications

        N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
        Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).
        Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.
      • Cellular localization

        Secreted and Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
      • Target information above from: UniProt accession P02786 The UniProt Consortium
        The Universal Protein Resource (UniProt) in 2010
        Nucleic Acids Res. 38:D142-D148 (2010) .

        Information by UniProt

      Images

      • SDS-PAGE - Recombinant Human Transferrin Receptor protein (ab159687)
        SDS-PAGE - Recombinant Human Transferrin Receptor protein (ab159687)
        ab159687 on a 12.5% SDS-PAGE stained with Coomassie Blue.

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (0)

      Publishing research using ab159687? Please let us know so that we can cite the reference in this datasheet.

      ab159687 has not yet been referenced specifically in any publications.

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