Recombinant Human Transglutaminase 5 protein (ab160436)

Our Abpromise guarantee covers the use of ab160436 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Alternative names
- Protein glutamine gamma glutamyltransferase 5
- Protein-glutamine gamma-glutamyltransferase 5
- PSS2
- TG(X)
- TGase 5
- TGase X
- TGase-5
- TGase5
- TGASEX
- Tgm5
- TGM5_HUMAN
- TGM6
- TGMX
- TGX
- Transglutaminase X
- Transglutaminase-5
see all
Function

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.
Tissue specificity

Expressed in foreskin keratinocytes.
Involvement in disease

Defects in TGM5 are a cause of peeling skin syndrome type A (APSS) [MIM:609796]. A non-inflammatory form of peeling skin syndrome, a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis. In APSS patients, skin peeling is strictly limited to the dorsa of the hands and feet, and it is accompanied by accompanied by painless erythema and spontaneous non-scarring healing. Ultrastructural and histological analysis shows a level of blistering high in the epidermis at the stratum granulosum-stratum corneum junction.
Sequence similarities

Belongs to the transglutaminase superfamily. Transglutaminase family.
Cellular localization

Cytoplasm. Associated with intermediate filaments.
Target information above from: UniProt accession O43548 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Human Transglutaminase 5 protein (ab160436)

ab160436 on a 12.5% SDS-PAGE stained with Coomassie Blue.

ab160436 has not yet been referenced specifically in any publications.

Publishing research using ab160436? Please let us know so that we can cite the reference in this datasheet.

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