Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
vinculin and TIR domain-containing protein B
Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
Ubiquitously expressed but with higher levels in liver.
Contains 1 TIR domain.
The N-terminal region is essential for activation of the IFNB promoter activity.