Recombinant Human TRIM37/MUL protein (ab167952)
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Overview
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Product nameRecombinant Human TRIM37/MUL protein
See all TRIM37/MUL proteins and peptides -
Protein lengthFull length protein
Description
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NatureRecombinant
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SourceBaculovirus infected Sf9 cells
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Amino Acid Sequence
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Accession
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SpeciesHuman
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SequenceMDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQ CPHCRAPLQL RELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENH HEKLSVFCWTCKKCICHQCALW GGMHGGHTFKPLAEIYEQHVTKVNEE VAKLRRRLMELISLVQEVERNVEAVRNAKDERVR EIRNAVEMMIARLD TQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISK SS EILMMFQQVHRKPMASFVTTPVPPDFTSELVPSYDSATFVLENFSTLRQR ADPVYSPP LQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSK YEYRVEMVHQSCNDPTKNII REFASDFEVGECWGYNRFFRLDLLANEG YLNPQNDTVILRFQVRSPTFFQKSRDQHWYIT QLEAAQTSYIQQINNL KERLTIELSRTQKSRDLSPPDNHLSPQNDDALETRAKKSACSDM LLEG GPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLVYEDEVNQLDGS SSSASS TATSNTEENDIDEETMSGENDVEYNNMELEEGELMEDAAAAG PAGSSHGYVGSSSRISRR THLCSAATSSLLDIDPLILIHLLDLKDRSS IENLWGLQPRPPASLLQPTASYSRKDKDQR KQQAMWRVPSDLKMLKRL KTQMAEVRCMKTDVKNTLSEIKSSSAASGDMQTSLFSADQAA LAACGT ENSGRLQDLGMELLAKSSVANCYIRNSTNKKSNSPKPARSSVAGSLSLRR AVDP GENSRSKGDCQTLSEGSPGSSQSGSRHSSPRALIHGSIGDILPK TEDRQCKALDSDAVVV AVFSGLPAVEKRRKMVTLGANAKGGHLEGLQM TDLENNSETGELQPVLPEGASAAPEEGM SSDSDIECDTENEEQEEHTS VGGFHDSFMVMTQPPDEDTHSSFPDGEQIGPEDLSFNTDE NSGR
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Molecular weight140 kDa including tags
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Amino acids1 to 964
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Tagsproprietary tag N-Terminus
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab167952 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Western blot
SDS-PAGE
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Purity> 80 % Densitometry.
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FormLiquid
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Additional notes
This product was previously labelled as TRIM37
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.50
Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.29% Sodium chloride
General Info
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Alternative names
- E3 ubiquitin protein ligase TRIM37
- E3 ubiquitin-protein ligase TRIM37
- KIAA0898
see all -
FunctionE3 ubiquitin-protein ligase.
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Tissue specificityUbiquitous.
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PathwayProtein modification; protein ubiquitination.
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Involvement in diseaseDefects in TRIM37 are the cause of mulibrey nanism (MUL) [MIM:253250]; also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common.
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Sequence similaritiesBelongs to the TRIM/RBCC family.
Contains 1 B box-type zinc finger.
Contains 1 MATH domain.
Contains 1 RING-type zinc finger. -
Post-translational
modificationsAuto-ubiquitinated. -
Cellular localizationCytoplasm > perinuclear region. Peroxisome. Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation.
- Information by UniProt
Images
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SDS-PAGE - Recombinant Human TRIM37/MUL protein (ab167952)SDS Page analysis of ab167952
Datasheets and documents
References
ab167952 has not yet been referenced specifically in any publications.
