Recombinant Human TRIM37/MUL protein (ab167952)
Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Purity: > 80% Densitometry
- Tags: proprietary tag N-Terminus
- Suitable for: WB, SDS-PAGE
Description
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Product name
Recombinant Human TRIM37/MUL protein
See all TRIM37/MUL proteins and peptides -
Purity
> 80 % Densitometry. -
Expression system
Baculovirus infected Sf9 cells -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQ CPHCRAPLQL RELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENH HEKLSVFCWTCKKCICHQCALW GGMHGGHTFKPLAEIYEQHVTKVNEE VAKLRRRLMELISLVQEVERNVEAVRNAKDERVR EIRNAVEMMIARLD TQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISK SS EILMMFQQVHRKPMASFVTTPVPPDFTSELVPSYDSATFVLENFSTLRQR ADPVYSPP LQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSK YEYRVEMVHQSCNDPTKNII REFASDFEVGECWGYNRFFRLDLLANEG YLNPQNDTVILRFQVRSPTFFQKSRDQHWYIT QLEAAQTSYIQQINNL KERLTIELSRTQKSRDLSPPDNHLSPQNDDALETRAKKSACSDM LLEG GPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLVYEDEVNQLDGS SSSASS TATSNTEENDIDEETMSGENDVEYNNMELEEGELMEDAAAAG PAGSSHGYVGSSSRISRR THLCSAATSSLLDIDPLILIHLLDLKDRSS IENLWGLQPRPPASLLQPTASYSRKDKDQR KQQAMWRVPSDLKMLKRL KTQMAEVRCMKTDVKNTLSEIKSSSAASGDMQTSLFSADQAA LAACGT ENSGRLQDLGMELLAKSSVANCYIRNSTNKKSNSPKPARSSVAGSLSLRR AVDP GENSRSKGDCQTLSEGSPGSSQSGSRHSSPRALIHGSIGDILPK TEDRQCKALDSDAVVV AVFSGLPAVEKRRKMVTLGANAKGGHLEGLQM TDLENNSETGELQPVLPEGASAAPEEGM SSDSDIECDTENEEQEEHTS VGGFHDSFMVMTQPPDEDTHSSFPDGEQIGPEDLSFNTDE NSGR -
Predicted molecular weight
140 kDa including tags -
Amino acids
1 to 964 -
Tags
proprietary tag N-Terminus
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Specifications
Our Abpromise guarantee covers the use of ab167952 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Western blot
SDS-PAGE
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Form
Liquid -
Additional notes
This product was previously labelled as TRIM37
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.50
Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.29% Sodium chloride
General Info
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Alternative names
- E3 ubiquitin protein ligase TRIM37
- E3 ubiquitin-protein ligase TRIM37
- KIAA0898
see all -
Function
E3 ubiquitin-protein ligase. -
Tissue specificity
Ubiquitous. -
Pathway
Protein modification; protein ubiquitination. -
Involvement in disease
Defects in TRIM37 are the cause of mulibrey nanism (MUL) [MIM:253250]; also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common. -
Sequence similarities
Belongs to the TRIM/RBCC family.
Contains 1 B box-type zinc finger.
Contains 1 MATH domain.
Contains 1 RING-type zinc finger. -
Post-translational
modificationsAuto-ubiquitinated. -
Cellular localization
Cytoplasm > perinuclear region. Peroxisome. Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab167952 has not yet been referenced specifically in any publications.