Recombinant Human TRIM37/MUL protein (ab167952)

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SDS-PAGE - Recombinant Human TRIM37/MUL protein (ab167952)

    Key features and details

    • Expression system: Baculovirus infected Sf9 cells
    • Purity: > 80% Densitometry
    • Tags: proprietary tag N-Terminus
    • Suitable for: WB, SDS-PAGE

    Description

    • Product name

      Recombinant Human TRIM37/MUL protein
      See all TRIM37/MUL proteins and peptides

    • Purity

      > 80 % Densitometry.

    • Expression system

      Baculovirus infected Sf9 cells

    • Accession

      O94972

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQ CPHCRAPLQL RELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENH HEKLSVFCWTCKKCICHQCALW GGMHGGHTFKPLAEIYEQHVTKVNEE VAKLRRRLMELISLVQEVERNVEAVRNAKDERVR EIRNAVEMMIARLD TQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISK SS EILMMFQQVHRKPMASFVTTPVPPDFTSELVPSYDSATFVLENFSTLRQR ADPVYSPP LQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSK YEYRVEMVHQSCNDPTKNII REFASDFEVGECWGYNRFFRLDLLANEG YLNPQNDTVILRFQVRSPTFFQKSRDQHWYIT QLEAAQTSYIQQINNL KERLTIELSRTQKSRDLSPPDNHLSPQNDDALETRAKKSACSDM LLEG GPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLVYEDEVNQLDGS SSSASS TATSNTEENDIDEETMSGENDVEYNNMELEEGELMEDAAAAG PAGSSHGYVGSSSRISRR THLCSAATSSLLDIDPLILIHLLDLKDRSS IENLWGLQPRPPASLLQPTASYSRKDKDQR KQQAMWRVPSDLKMLKRL KTQMAEVRCMKTDVKNTLSEIKSSSAASGDMQTSLFSADQAA LAACGT ENSGRLQDLGMELLAKSSVANCYIRNSTNKKSNSPKPARSSVAGSLSLRR AVDP GENSRSKGDCQTLSEGSPGSSQSGSRHSSPRALIHGSIGDILPK TEDRQCKALDSDAVVV AVFSGLPAVEKRRKMVTLGANAKGGHLEGLQM TDLENNSETGELQPVLPEGASAAPEEGM SSDSDIECDTENEEQEEHTS VGGFHDSFMVMTQPPDEDTHSSFPDGEQIGPEDLSFNTDE NSGR

      • Predicted molecular weight

        140 kDa including tags

      • Amino acids

        1 to 964

      • Tags

        proprietary tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab167952 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Western blot

      SDS-PAGE

    • Form

      Liquid

    • Additional notes

       This product was previously labelled as TRIM37

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 7.50
      Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.29% Sodium chloride

    General Info

    • Alternative names

      • E3 ubiquitin protein ligase TRIM37
      • E3 ubiquitin-protein ligase TRIM37
      • KIAA0898
      • MUL
      • MUL protein
      • Mulibrey nanism gene
      • Mulibrey nanism protein
      • POB 1
      • POB1
      • RING B box coiled coil protein
      • TEF 3
      • TEF3
      • TRI37_HUMAN
      • TRIM 37
      • Trim37
      • Tripartite motif containing 37
      • Tripartite motif containing 37 protein
      • Tripartite motif containing protein 37
      • Tripartite motif-containing protein 37
      see all

    • Function

      E3 ubiquitin-protein ligase.

    • Tissue specificity

      Ubiquitous.

    • Pathway

      Protein modification; protein ubiquitination.

    • Involvement in disease

      Defects in TRIM37 are the cause of mulibrey nanism (MUL) [MIM:253250]; also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common.

    • Sequence similarities

      Belongs to the TRIM/RBCC family.
      Contains 1 B box-type zinc finger.
      Contains 1 MATH domain.
      Contains 1 RING-type zinc finger.

    • Post-translational
      modifications

      Auto-ubiquitinated.

    • Cellular localization

      Cytoplasm > perinuclear region. Peroxisome. Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human TRIM37/MUL protein (ab167952)
      SDS-PAGE - Recombinant Human TRIM37/MUL protein (ab167952)
      SDS Page analysis of ab167952

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab167952? Please let us know so that we can cite the reference in this datasheet.

    ab167952 has not yet been referenced specifically in any publications.

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