Product nameRecombinant Human TRIO protein
See all TRIO proteins and peptides
Protein lengthProtein fragment
Amino Acid Sequence
SequenceERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKG KDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIA YCQNKPKSEH
Amino acids1961 to 2070
Tagsproprietary tag N-Terminus
Our Abpromise guarantee covers the use of ab159748 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.31% Glutathione, 0.79% Tris HCl
FunctionPromotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.
Tissue specificityHighly expressed in heart, skeletal muscle, brain, pancreas, placenta, liver, kidney and lung.
Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Contains 1 CRAL-TRIO domain.
Contains 2 DH (DBL-homology) domains.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 2 PH domains.
Contains 1 protein kinase domain.
Contains 2 SH3 domains.
Contains 4 spectrin repeats.
DomainThe N-terminal DBL/GEF domain specifically catalyzes nucleotide exchange for RAC1, leading to the activation of Jun kinase and the production of membrane ruffles. The second DBL/GEF domain is an exchange factor for rhoa and induces the formation of stress fibers.
modificationsPhosphorylated on serine residue(s).
- Information by UniProt
ab159748 has not yet been referenced specifically in any publications.