Overview

  • Product name
    Recombinant Human TRPV5 protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLL RASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME
    • Amino acids
      1 to 100
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab153420 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Calcium transport protein 2
    • Calcium transporter 2
    • CAT 2
    • CAT2
    • ECaC
    • ECAC 1
    • ECaC1
    • Epithelial calcium channel 1
    • Osm 9 like TRP channel 3
    • Osm-9-like TRP channel 3
    • OTRPC 3
    • OTRPC3
    • Transient receptor potential cation channel subfamily V member 5
    • TRPV 5
    • TrpV5
    • TRPV5_HUMAN
    see all
  • Function
    Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
  • Tissue specificity
    Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.
  • Sequence similarities
    Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily.
    Contains 5 ANK repeats.
  • Post-translational
    modifications
    Glycosylated.
  • Cellular localization
    Apical cell membrane. Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human TRPV5 protein (ab153420)
    SDS-PAGE - Recombinant Human TRPV5 protein (ab153420)
    ab153420 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab153420 has not yet been referenced specifically in any publications.

Publishing research using ab153420? Please let us know so that we can cite the reference in this datasheet.

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