Recombinant Human TSPYL1 protein (ab159752)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MSGLDGVKRTTPLQTHSIIISDQVPSDQDAHQYLRLRDQSEATQVMAEPG EGGSETVALPPPPPSEEGGVPQDAAGRGGTPQIRVVGGRGHVAIKAGQEE GQPPAEGLAAASVVMAADRSLKKGVQGGEKALEICGAQRSASELTAGAEA EAEEVKTGKCATVSAAVAERESAEVVVKEGLAEKEVMEEQMEVEEQPPEG EEIEVAEEDRLEEEAREEEGPWPLHEALRMDPLEAIQLELDTVNAQADRA FQQLEHKFGRMRRHYLERRNYIIQNIPGFWMTAFRNHPQLSAMIRGQDAE MLRYITNLEVKELRHPRTGCKFKFFFRRNPYFRNKLIVKEYEVRSSGRVV SLSTPIIWRRGHEPQSFIRRNQDLICSFFTWFSDHSLPESDKIAEIIKED LWPNPLQYYLLREGVRRARRRPLREPVEIPRPFGFQSG
    • Amino acids
      1 to 438
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab159752 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • SIDDT
    • Testis specific like protein Y encoded
    • Testis specific Y encoded like protein 1
    • Testis-specific Y-encoded-like protein 1
    • TSPY like
    • TSPY like 1
    • TSPY like protein 1
    • TSPY-like protein 1
    • TSPYL
    • TSPYL1
    • TSYL1_HUMAN
    see all
  • Tissue specificity
    Expressed in testis, ovary, liver, spleen, brain, kidney, prostate, lung, liver, and heart.
  • Involvement in disease
    Defects in TSPYL1 are the cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT) [MIM:608800]. SIDDT is an autosomal recessive disorder. Affected infants appear normal at birth, develop signs of visceroautonomic dysfunction early in life, and die before 12 months of age of abrupt cardiorespiratory arrest. Features included bradycardia, hypothermia, severe gastroesophageal reflux, laryngospasm, bronchospasm, and abnormal cardiorespiratory patterns during sleep. Genotypic males with SIDDT had fetal testicular dysgenesis and ambiguous genitalia, with findings such as intraabdominal testes, dysplastic testes, deficient fetal testosterone production, fusion and rugation of the gonadal sac, and partial development of the penile shaft. Female sexual development was normal. Affected infants had an unusual staccato cry, similar to the cry of a goat.
  • Sequence similarities
    Belongs to the nucleosome assembly protein (NAP) family.
  • Cellular localization
    Nucleus > nucleolus.
  • Information by UniProt

Images

  • ab159752 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab159752 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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