Overview

Description

  • Nature

    Recombinant
  • Source

    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      64 kDa including tags
    • Amino acids

      2 to 350

Specifications

Our Abpromise guarantee covers the use of ab131676 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

  • Purity

    > 95 % SDS-PAGE.
    Assessed by densitometry.
  • Form

    Liquid
  • Additional notes

     This product was previously labelled as TWF1

     

     This product was previously labelled as TWF1

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.005% DTT, 0.79% Tris HCl, 0.003% EDTA, 0.88% Sodium chloride

General Info

  • Alternative names

    • A6
    • A6 protein tyrosine kinase
    • MGC105817
    • MGC23788
    • MGC41876
    • Protein A6
    • Protein tyrosine kinase 9
    • PTK9
    • PTK9 protein tyrosine kinase 9
    • TWF 1
    • twf1
    • TWF1_HUMAN
    • Twinfilin
    • Twinfilin 1
    • Twinfilin actin binding protein, homolog 1
    • Twinfilin, actin-binding protein, homolog 1 (Drosophila)
    • Twinfilin, Drosophila, homolog of, 1
    • Twinfilin-1
    see all
  • Function

    Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.
  • Tissue specificity

    Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.
  • Sequence similarities

    Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
    Contains 2 ADF-H domains.
  • Post-translational
    modifications

    Phosphorylated on serine and threonine residues.
  • Cellular localization

    Cytoplasm. Cytoplasm > cytoskeleton. Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts.
  • Information by UniProt

Images

  • The purity of ab131676 was determined to be >95% by densitometry.

References

ab131676 has not yet been referenced specifically in any publications.

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