Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQEPVGRWD QDYDRAVLPLLDAQQPCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKML YAATRATVKKEFGGGHIKDELFGTVKDDLSFAGYQKHLSSCAAPAPLTSA ERELQQIRINEVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKMVNY IQMKLDLERETIELVHTEPTDVAQLPSRVPRDAARYHFFLYKHTHEGDPL ESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAKKIEIGDG AELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRGHKRLIRGPGENGDDS
    • Amino acids
      1 to 349
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab161423 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • A6 related protein
    • A6-related protein
    • A6r
    • A6RP
    • hA6RP
    • MSTP011
    • Protein tyrosine kinase 9 like
    • Protein tyrosine kinase 9-like
    • PTK 9L
    • PTK9L
    • PTK9L protein tyrosine kinase 9 like
    • TWF 2
    • Twf2
    • TWF2_HUMAN
    • Twinfilin 1 like protein
    • Twinfilin 2
    • Twinfilin actin binding protein homolog 2
    • Twinfilin like protein
    • Twinfilin-1-like protein
    • Twinfilin-2
    • Twinfilin2
    see all
  • Function
    Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia.
  • Tissue specificity
    Ubiquitously expressed (at protein level).
  • Sequence similarities
    Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
    Contains 2 ADF-H domains.
  • Post-translational
    modifications
    In vitro, phosphorylated by PRKCZ, CK2 and SRC.
  • Cellular localization
    Cytoplasm > cytoskeleton. Cytoplasm > perinuclear region. Cell projection > stereocilium. Perinuclear and G-actin-rich cortical actin structure sublocalization.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human TWF2 protein (ab161423)
    SDS-PAGE - Recombinant Human TWF2 protein (ab161423)
    ab161423 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab161423 has not yet been referenced specifically in any publications.

Publishing research using ab161423? Please let us know so that we can cite the reference in this datasheet.

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