Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      CNKALCASDV SKCLIQELCQ CRPGEGNCSC CKECMLCLGA LWDECCDCVG MCNPRNYSDT PPTSKSTVEE LHEPIPSLFR ALTEGDTQLN WNIVSFPVAE ELSHHENLVS FLETVNQPHH QNVSVPSNNV HAPYSSDKEH MCTVVYFDDC MSIHQCKISC ESMGASKYRW FHNACCECIG PECIDYGSKT VKCMNCMF
    • Amino acids
      26 to 223

Specifications

Our Abpromise guarantee covers the use of ab50231 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

  • Endotoxin level
    < 0.100 Eu/µg
  • Form
    Lyophilised
  • Additional notes

     This product was previously labelled as TWSG1

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Endotoxin level is less than 0.1 ng per µg (1EU/µg).

  • Reconstitution
    Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4oC for 1 week or -20oC for future use

General Info

  • Alternative names
    • PSEC0250
    • twisted gastrulation homolog 1 (Drosophila)
    • TSG
    • TSG1
    • Twisted gastrulation BMP signaling modulator 1
    • Twisted gastrulation homolog 1
    • Twisted gastrulation protein
    • Twisted gastrulation protein homolog 1
    • TWSG1
    • TWSG1_HUMAN
    see all
  • Function
    May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.
  • Sequence similarities
    Belongs to the twisted gastrulation protein family.
  • Developmental stage
    Expressed in brain throughout development.
  • Domain
    The N-terminal domain is sufficient to interact with BMP4.
  • Cellular localization
    Secreted.
  • Information by UniProt

References

ab50231 has not yet been referenced specifically in any publications.

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